On January 28th, collaborative research teams led by Professors Shao Zhenhua/Yan Wei and Professor Yang Shengyong from the State Key Laboratory of Biotherapy at West China Hospital, in partnership with the teams of Wang Xiaohui from the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, and Liu Jianfeng from Huazhong University of Science and Technology, published a groundbreaking research paper in the journal Nature.
The paper, titled "Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signaling," reveals a novel mechanism involving a non-canonical Gi signaling pathway mediated by the serotonin 2A receptor (5-HT2AR). Based on this discovery, the team has developed new antidepressant candidates with significant potential for clinical translation. This finding provides a crucial foundation for innovating therapeutic strategies for related psychiatric disorders.
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